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染色体与习惯性流产 Chromosome and habitual abortion

  • 来源:陈凤林
  • 作者:陈凤林
  • 更新日期:2019-05-29 16:28
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在习惯性流产过程中,还有这样一类患者,就是因为染色体异常而认为导致习惯性流产,无法治愈。那么染色体因素的习惯性流产要怎么治疗?临床上很多医患认为夫妇染色体异常能够导致流产,那么染色体异常真的会流产吗? In the process of habitual abortion, the

在习惯性流产过程中,还有这样一类患者,就是因为染色体异常而认为导致习惯性流产,无法治愈。那么染色体因素的习惯性流产要怎么治疗?临床上很多医患认为夫妇染色体异常能够导致流产,那么染色体异常真的会流产吗?

In the process of habitual abortion, there is also a type of patient who believes that habitual abortion is caused by chromosomal abnormalities and can not be cured. So how does chromosome factor habitual abortion want to treat? Clinically, many doctors and patients believe that couples with chromosomal abnormalities can lead to abortion, so can chromosomal abnormalities really be aborted?

其实夫妇染色体异常不会导致习惯性流产。原因是,染色体异常形成于精卵结合之初,染色体异常有三种情况:致死型异常;致残型异常;携带型异常。致死型,是染色体严重变异,结局是胚胎枯萎而自然流产,不会有出生婴儿。致残型,是染色体中度异常,多是染色体数量变化,如21三体,22三体,特纳综合征(多一条Y染色体)等出生的都是残疾人,基本都无生育能力。携带型,是轻度染色体异常,如平衡易位、倒位[46,XY,t(5,12)]等,遗传信息并不少,只是染色体片段发生位移,这样的人外表和生殖腺正常,也不会导致流产,充其量出生的后代染色体与上代一样而已。正所谓龙生龙,凤生凤,老鼠生来会打洞。详细,可以点击《习惯性流产与染色体》查看。

In fact, couples with chromosomal abnormalities do not lead to habitual abortion. The reason is that chromosomal abnormalities are formed at the beginning of sperm egg binding. There are three kinds of chromosomal abnormalities: fatal abnormalities; Disabling abnormalities; Portable anomaly. The lethal type is a serious chromosome variation. The outcome is that the embryo withers and naturally miscarries, and there will be no baby born. The disability type is a moderately abnormal chromosome, and it is mostly a change in the number of chromosomes. For example, 21 trisomes, 22 trisomes, Turner syndrome(more than one Y chromosome), etc., are all born with disabilities and are basically infertile. Portable type, is a mild chromosomal anomaly, such as equilibrium transposition, inversion[ 46, XY, T(5, 12)] And so on, there is a lot of genetic information, but the chromosomal fragments are displaced. Such a person's appearance and gonad are normal, and it will not lead to abortion. At best, the offspring born have the same chromosomes as the previous generation. The so-called dragon born Dragon, Phoenix born Phoenix, mice born to make holes. For details, click "Customary Abortion and Chromosomes" to view.

综上所述,致死型染色体异常一定流产;致残型,无生育能力。所以,因为习惯性流产来就诊的,如果有染色体异常,也只有携带型一种可能。这种类型又不会导致习惯性流产。如果说夫妇一方有携带型染色体异常就一定流产,那么世界上岂不是没有染色体异常的人了?由此可知,习惯性流产病因筛查染色体项目无任何意义。习惯性流产病因筛查时,不应把夫妇染色体检查作为重点,把夫妇染色体异常有习惯性流产者列为不治之症更是错上加错。

In summary, fatal chromosomal abnormalities must be aborted; Disabled, infertile. Therefore, because of habitual abortion, if there are chromosomal abnormalities, there is only one possibility of carrying. This type does not lead to habitual abortion. If one of the couples has a portable chromosomal abnormality, it must be aborted. Then isn't there a person with no chromosomal abnormality in the world? It can be seen that the etiology of habitual abortion screening chromosome project has no meaning. When screening for the etiology of habitual abortion, couples should not focus on chromosome examination. It is even more wrong to list couples with abnormal chromosomal habitual abortions as incurable diseases.

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