染色体46,XX,del(5)(q13)怀孕流产做试管婴儿有用吗?Chromosome 46, XX, Del(5)(q13) Is pregnant miscarriage useful as a test-tube baby?

染色体46,XX,del(5)(q13)对生育有没有影响?怀了总是流产，让去做试管。

Does chromosome 46, XX, Del(5)(q13) affect fertility? Always having an miscarriage, let it be a test tube.

陈凤林教授指出：染色体46,XX,del(5)(q13)属于染色体缺失，本身属于携带型异常，不会影响到胎儿的生长发育，在早期流产的病例中，这种情况多与免疫性抗胚胎抗体高有关系，可以在孕前进行免疫干预治疗，孕后再加强则不再流产。

Professor Chenfenglin pointed out: Chromosome 46, XX, Del(5)(q13) belongs to chromosome loss and is itself a portable anomaly that does not affect the growth and development of the fetus. In cases of early miscarriage, This situation is mostly related to immuno-anti-embryo antibody Gaoyou, which can be treated with immune intervention before conception, and after pregnancy, it is no longer aborted.

临床上很多医患认为夫妇染色体异常能够导致流产，那么染色体异常真的会流产吗?

Clinically, many doctors and patients believe that couples with chromosomal abnormalities can lead to miscarriage, so can chromosomal abnormalities really be aborted?

其实夫妇染色体异常不会导致习惯性流产。原因是，染色体异常形成于精卵结合之初，染色体异常有三种情况：

In fact, couples with chromosomal abnormalities do not lead to habitual miscarriage. The reason is that chromosomal abnormalities are formed at the beginning of sperm egg binding. There are three types of chromosomal abnormalities:

致死型异常;致残型异常;携带型异常。致死型，是染色体严重变异，结局是胚胎枯萎而自然流产，不会有出生婴儿。

Lethal abnormalities; Disabling abnormalities; Portable anomaly. The lethal type is a serious chromosome variation. The outcome is that the embryo withers and naturally miscarries, and there will be no baby born.

致残型,是染色体中度异常，多是染色体数量变化，如21三体，22三体，特纳综合征(多一条Y染色体)等出生的都是残疾人，基本都无生育能力。

The disability type is a moderately abnormal chromosome, and it is mostly a change in the number of chromosomes. For example, 21 trisomes, 22 trisomes, Turner syndrome(more than one Y chromosome), etc., are all born with disabilities and are basically infertile.

携带型，是轻度染色体异常，如平衡易位、倒位[46，XY，t(5，12)]等，遗传信息并不少，只是染色体片段发生位移，这样的人外表和生殖腺正常，也不会导致流产，充其量出生的后代染色体与上代一样而已。

Portable type, is a mild chromosomal anomaly, such as equilibrium transposition, inversion[ 46, XY, T(5, 12)] And so on, there is a lot of genetic information, but the chromosomal fragments are displaced. Such a person's appearance and gonad are normal, and it will not lead to miscarriage. At best, the offspring born have the same chromosomes as the previous generation.

正所谓龙生龙，凤生凤，老鼠生来会打洞。

The so-called dragon born Dragon, Phoenix born Phoenix, mice born to make holes.